Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner

Cucurbitacins are a class of triterpenoids widely distributed in plant kingdom with potent anti-cancer activities both in vitro and in vivo by inducing cycle arrest, autophagy, and apoptosis. Cucurbitacin B (Cuc B), could induce S or G2/M cell cycle arrest in cancer cells while the detailed mechanis...

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Detalles Bibliográficos
Autores principales: Guo, Jiajie, Wu, Guosheng, Bao, Jiaolin, Hao, Wenhui, Lu, Jinjian, Chen, Xiuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913755/
https://www.ncbi.nlm.nih.gov/pubmed/24505404
http://dx.doi.org/10.1371/journal.pone.0088140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913755/
https://www.ncbi.nlm.nih.gov/pubmed/24505404
http://dx.doi.org/10.1371/journal.pone.0088140

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