Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes

Heat shock protein 90 (Hsp90) is a molecular chaperone essential for the stability and function of multiple cellular client proteins, a number of which have been implicated in the pathogenesis of breast cancer. Here we undertook a comprehensive evaluation of the activity of ganetespib, a selective H...

Descripción completa

Detalles Bibliográficos
Autores principales: Friedland, Julie C., Smith, Donald L., Sang, Jim, Acquaviva, Jaime, He, Suqin, Zhang, Chaohua, Proia, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913847/
https://www.ncbi.nlm.nih.gov/pubmed/23686707
http://dx.doi.org/10.1007/s10637-013-9971-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913847/
https://www.ncbi.nlm.nih.gov/pubmed/23686707
http://dx.doi.org/10.1007/s10637-013-9971-6

Ejemplares similares