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Synergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines

Treatments for lymphomas include gemcitabine (Gem) and clofarabine (Clo) which inhibit DNA synthesis. To improve their cytotoxicity, we studied their synergism with the alkyl phospholipid edelfosine (Ed). Exposure of the J45.01 and SUP-T1 (T-cell) and the OCI-LY10 (B-cell) lymphoma cell lines to IC(...

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Detalles Bibliográficos
Autores principales: Valdez, B C, Zander, A R, Song, G, Murray, D, Nieto, Y, Li, Y, Champlin, R E, Andersson, B S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913938/
https://www.ncbi.nlm.nih.gov/pubmed/24413065
http://dx.doi.org/10.1038/bcj.2013.69