A two-domain elevator mechanism for sodium/proton antiport

Sodium/proton (Na(+)/H(+)) antiporters, located at the plasma membrane in every cell, are vital for cell homeostasis(1). In humans, their dysfunction has been linked to diseases, such as, hypertension, heart failure and epilepsy and they are well-established drug targets(2). The best understood mode...

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Detalles Bibliográficos
Autores principales: Lee, Chiara, Kang, Hae Joo, von Ballmoos, Christoph, Newstead, Simon, Uzdavinys, Povilas, Dotson, David L., Iwata, So, Beckstein, Oliver, Cameron, Alexander D., Drew, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914025/
https://www.ncbi.nlm.nih.gov/pubmed/23995679
http://dx.doi.org/10.1038/nature12484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914025/
https://www.ncbi.nlm.nih.gov/pubmed/23995679
http://dx.doi.org/10.1038/nature12484

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