High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic alterations at the D4Z4 macrosatellite repeat locus on chromosome 4, resulting in inappropriate expression of the DUX4 protein. The DUX4 protein is therefore the primary molecular target for therapeutic intervention. M...

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Detalles Bibliográficos
Autores principales: Bosnakovski, Darko, Choi, Si Ho, Strasser, Jessica M, Toso, Erik A, Walters, Michael A, Kyba, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914678/
https://www.ncbi.nlm.nih.gov/pubmed/24484587
http://dx.doi.org/10.1186/2044-5040-4-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914678/
https://www.ncbi.nlm.nih.gov/pubmed/24484587
http://dx.doi.org/10.1186/2044-5040-4-4

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