Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice

The reduction of functional β cell mass is a key feature of type 2 diabetes. Here, we studied metabolic functions and islet gene expression profiles of C57BL/6J mice with naturally occurring nicotinamide nucleotide transhydrogenase (NNT) deletion mutation, a widely used model of diet-induced obesity...

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Detalles Bibliográficos
Autores principales: Roat, Regan, Rao, Vandana, Doliba, Nicolai M., Matschinsky, Franz M., Tobias, John W., Garcia, Eden, Ahima, Rexford S., Imai, Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914796/
https://www.ncbi.nlm.nih.gov/pubmed/24505268
http://dx.doi.org/10.1371/journal.pone.0086815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914796/
https://www.ncbi.nlm.nih.gov/pubmed/24505268
http://dx.doi.org/10.1371/journal.pone.0086815

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