Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin

BACKGROUND: Duchenne muscle dystrophy (DMD) afflicts 1 million boys in the US and has few effective treatments. Constitutive transgenic expression of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α improves skeletal muscle function in the murine...

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Detalles Bibliográficos
Autores principales: Chan, Mun Chun, Rowe, Glenn C, Raghuram, Srilatha, Patten, Ian S, Farrell, Caitlin, Arany, Zolt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914847/
https://www.ncbi.nlm.nih.gov/pubmed/24447845
http://dx.doi.org/10.1186/2044-5040-4-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914847/
https://www.ncbi.nlm.nih.gov/pubmed/24447845
http://dx.doi.org/10.1186/2044-5040-4-2

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