Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity

Phosphorylation has been shown to have a significant impact on expanded huntingtin-mediated cellular toxicity. Several phosphorylation sites have been identified on the huntingtin (Htt) protein. To find new potential therapeutic targets for Huntington's Disease (HD), we used mass spectrometry t...

Descripción completa

Detalles Bibliográficos
Autores principales: Watkin, Erin E., Arbez, Nicolas, Waldron-Roby, Elaine, O'Meally, Robert, Ratovitski, Tamara, Cole, Robert N., Ross, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914950/
https://www.ncbi.nlm.nih.gov/pubmed/24505464
http://dx.doi.org/10.1371/journal.pone.0088284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914950/
https://www.ncbi.nlm.nih.gov/pubmed/24505464
http://dx.doi.org/10.1371/journal.pone.0088284

Ejemplares similares