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Optimal CD4 Count for Initiating HIV Treatment: Impact of CD4 Observation Frequency and Grace Periods, and Performance of Dynamic Marginal Structural Models

BACKGROUND: In HIV infection, dynamic marginal structural models have estimated the optimal CD4 for treatment initiation to minimize AIDS/death. The impact of CD4 observation frequency and grace periods (permitted delay to initiation) on the optimal regimen has not been investigated nor has the perf...

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Detalles Bibliográficos
Autores principales: Ewings, Fiona M., Ford, Deborah, Walker, A. Sarah, Carpenter, James, Copas, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914951/
https://www.ncbi.nlm.nih.gov/pubmed/24487204
http://dx.doi.org/10.1097/EDE.0000000000000043