High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers

Toxicity is a major cause of failure in drug discovery and development, and whilst robust toxicological testing occurs, efficiency could be improved if compounds with cytotoxic characteristics were identified during primary compound screening. The use of high-content imaging in primary screening is...

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Detalles Bibliográficos
Autores principales: Martin, Heather L., Adams, Matthew, Higgins, Julie, Bond, Jacquelyn, Morrison, Ewan E., Bell, Sandra M., Warriner, Stuart, Nelson, Adam, Tomlinson, Darren C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914966/
https://www.ncbi.nlm.nih.gov/pubmed/24505478
http://dx.doi.org/10.1371/journal.pone.0088338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914966/
https://www.ncbi.nlm.nih.gov/pubmed/24505478
http://dx.doi.org/10.1371/journal.pone.0088338

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