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The Treg-Specific Demethylated Region Stabilizes Foxp3 Expression Independently of NF-κB Signaling
Regulatory T cells (Tregs) obtain immunosuppressive capacity by the upregulation of forkhead box protein 3 (Foxp3), and persistent expression of this transcription factor is required to maintain their immune regulatory function and ensure immune homeostasis. Stable Foxp3 expression is achieved throu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914969/ https://www.ncbi.nlm.nih.gov/pubmed/24505473 http://dx.doi.org/10.1371/journal.pone.0088318 |