Fusion of Ubiquitin to HIV Gag Impairs Human Monocyte-Derived Dendritic Cell Maturation and Reduces Ability to Induce Gag T Cell Responses

The efficient induction of CD8 T cell immunity is dependent on the processing and presentation of antigen on MHC class I molecules by professional antigen presenting cells (APC). To develop an improved T cell vaccine for HIV we investigated whether fusing the ubiquitin gene to the N terminus of the...

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Detalles Bibliográficos
Autores principales: Herath, Shanthi, Benlahrech, Adel, Papagatsias, Timos, Athanasopoulos, Takis, Bouzeboudjen, Zineb, Hervouet, Catherine, Klavinskis, Linda, Meiser, Andrea, Kelleher, Peter, Dickson, George, Patterson, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914991/
https://www.ncbi.nlm.nih.gov/pubmed/24505475
http://dx.doi.org/10.1371/journal.pone.0088327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914991/
https://www.ncbi.nlm.nih.gov/pubmed/24505475
http://dx.doi.org/10.1371/journal.pone.0088327

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