Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells

BACKGROUND: Alpha-1-syntrophin (SNTA1) has been implicated in the activation of Rac1. However, the underlying mechanism has not yet been explored. Here, we show that a novel complex, involving SNTA1, P66shc, and Grb2 proteins, is involved in Rac1 activation. METHODS: Co-immunoprecipitation assays we...

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Detalles Bibliográficos
Autores principales: Bhat, H F, Baba, R A, Adams, M E, Khanday, F A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915110/
https://www.ncbi.nlm.nih.gov/pubmed/24434436
http://dx.doi.org/10.1038/bjc.2013.723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915110/
https://www.ncbi.nlm.nih.gov/pubmed/24434436
http://dx.doi.org/10.1038/bjc.2013.723

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