Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis

BACKGROUND: Developmental arrest of fetal germ cells may lead to neoplastic transformation and formation of germ cell tumours via carcinoma in situ (CIS) cells. Normal fetal germ cell development requires complete erasure and re-establishment of DNA methylation. In contrast to normal spermatogonia,...

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Detalles Bibliográficos
Autores principales: Kristensen, D G, Nielsen, J E, Jørgensen, A, Skakkebæk, N E, Rajpert-De Meyts, E, Almstrup, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915112/
https://www.ncbi.nlm.nih.gov/pubmed/24292451
http://dx.doi.org/10.1038/bjc.2013.727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915112/
https://www.ncbi.nlm.nih.gov/pubmed/24292451
http://dx.doi.org/10.1038/bjc.2013.727

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