Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma

BACKGROUND: microRNA-9 is a key regulator of neuronal development aberrantly expressed in brain malignancies, including medulloblastoma. The mechanisms by which microRNA-9 contributes to medulloblastoma pathogenesis remain unclear, and factors that regulate this process have not been delineated. MET...

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Detalles Bibliográficos
Autores principales: Fiaschetti, G, Abela, L, Nonoguchi, N, Dubuc, A M, Remke, M, Boro, A, Grunder, E, Siler, U, Ohgaki, H, Taylor, M D, Baumgartner, M, Shalaby, T, Grotzer, M A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915127/
https://www.ncbi.nlm.nih.gov/pubmed/24346283
http://dx.doi.org/10.1038/bjc.2013.764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915127/
https://www.ncbi.nlm.nih.gov/pubmed/24346283
http://dx.doi.org/10.1038/bjc.2013.764

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