AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL

The requirement that leukemic GATA1 mutations be present in cells harboring trisomy 21 led to the discovery that overexpression of ERG drives aberrant megakaryopoiesis. Given that constitutive PI3K/AKT signaling is a frequent component of hematologic malignancies and the relationship between AKT and...

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Detalles Bibliográficos
Autores principales: Stankiewicz, Monika J., Crispino, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915509/
https://www.ncbi.nlm.nih.gov/pubmed/23380710
http://dx.doi.org/10.1038/leu.2013.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915509/
https://www.ncbi.nlm.nih.gov/pubmed/23380710
http://dx.doi.org/10.1038/leu.2013.33

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