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AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL
The requirement that leukemic GATA1 mutations be present in cells harboring trisomy 21 led to the discovery that overexpression of ERG drives aberrant megakaryopoiesis. Given that constitutive PI3K/AKT signaling is a frequent component of hematologic malignancies and the relationship between AKT and...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915509/ https://www.ncbi.nlm.nih.gov/pubmed/23380710 http://dx.doi.org/10.1038/leu.2013.33 |