Dovitinib induces mitotic defects and activates the G(2) DNA damage checkpoint

Dovitinib (TKI258; formerly CHIR-258) is an orally bioavailable inhibitor of multiple receptor tyrosine kinases. Interestingly, Dovitinib triggered a G(2)/M arrest in cancer cell lines from diverse origins including HeLa, nasopharyngeal carcinoma, and hepatocellular carcinoma. Single-cell analysis r...

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Detalles Bibliográficos
Autores principales: Man, Wing Yu, Mak, Joyce PY, Poon, Randy YC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916126/
https://www.ncbi.nlm.nih.gov/pubmed/24238094
http://dx.doi.org/10.1111/jcmm.12176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916126/
https://www.ncbi.nlm.nih.gov/pubmed/24238094
http://dx.doi.org/10.1111/jcmm.12176

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