The Free Energy Profile of Tubulin Straight-Bent Conformational Changes, with Implications for Microtubule Assembly and Drug Discovery

αβ-tubulin dimers need to convert between a ‘bent’ conformation observed for free dimers in solution and a ‘straight’ conformation required for incorporation into the microtubule lattice. Here, we investigate the free energy landscape of αβ-tubulin using molecular dynamics simulations, emphasizing i...

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Detalles Bibliográficos
Autores principales: Peng, Lili X., Hsu, Monica T., Bonomi, Massimiliano, Agard, David A., Jacobson, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916224/
https://www.ncbi.nlm.nih.gov/pubmed/24516374
http://dx.doi.org/10.1371/journal.pcbi.1003464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916224/
https://www.ncbi.nlm.nih.gov/pubmed/24516374
http://dx.doi.org/10.1371/journal.pcbi.1003464

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