Compact Modeling of Allosteric Multisite Proteins: Application to a Cell Size Checkpoint

We explore a framework to model the dose response of allosteric multisite phosphorylation proteins using a single auxiliary variable. This reduction can closely replicate the steady state behavior of detailed multisite systems such as the Monod-Wyman-Changeux allosteric model or rule-based models. O...

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Detalles Bibliográficos
Autores principales: Enciso, Germán, Kellogg, Douglas R., Vargas, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916233/
https://www.ncbi.nlm.nih.gov/pubmed/24516371
http://dx.doi.org/10.1371/journal.pcbi.1003443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916233/
https://www.ncbi.nlm.nih.gov/pubmed/24516371
http://dx.doi.org/10.1371/journal.pcbi.1003443

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