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Compact Modeling of Allosteric Multisite Proteins: Application to a Cell Size Checkpoint
We explore a framework to model the dose response of allosteric multisite phosphorylation proteins using a single auxiliary variable. This reduction can closely replicate the steady state behavior of detailed multisite systems such as the Monod-Wyman-Changeux allosteric model or rule-based models. O...
Autores principales: | Enciso, Germán, Kellogg, Douglas R., Vargas, Arturo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916233/ https://www.ncbi.nlm.nih.gov/pubmed/24516371 http://dx.doi.org/10.1371/journal.pcbi.1003443 |
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