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Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association

Transcription factors (TFs) are fundamental controllers of cellular regulation that function in a complex and combinatorial manner. Accurate identification of a transcription factor's targets is essential to understanding the role that factors play in disease biology. However, due to a high fal...

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Detalles Bibliográficos
Autores principales: Karczewski, Konrad J., Snyder, Michael, Altman, Russ B., Tatonetti, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916285/
https://www.ncbi.nlm.nih.gov/pubmed/24516403
http://dx.doi.org/10.1371/journal.pgen.1004122