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An alternate pathophysiologic paradigm of sepsis and septic shock: Implications for optimizing antimicrobial therapy
The advent of modern antimicrobial therapy following the discovery of penicillin during the 1940s yielded remarkable improvements in case fatality rate of serious infections including septic shock. Since then, pathogens have continuously evolved under selective antimicrobial pressure resulting in a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916387/ https://www.ncbi.nlm.nih.gov/pubmed/24184742 http://dx.doi.org/10.4161/viru.26913 |