Activated α(2)-Macroglobulin Binding to Cell Surface GRP78 Induces T-Loop Phosphorylation of Akt1 by PDK1 in Association with Raptor

PDK1 phosphorylates multiple substrates including Akt by PIP(3)-dependent mechanisms. In this report we provide evidence that in prostate cancer cells stimulated with activated α(2)-macroglobulin (α(2)M*) PDK1 phosphorylates Akt in the T-loop at Thr(308) by using Raptor in the mTORC1 complex as a sc...

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Detalles Bibliográficos
Autores principales: Misra, Uma Kant, Pizzo, Salvatore Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916429/
https://www.ncbi.nlm.nih.gov/pubmed/24516643
http://dx.doi.org/10.1371/journal.pone.0088373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916429/
https://www.ncbi.nlm.nih.gov/pubmed/24516643
http://dx.doi.org/10.1371/journal.pone.0088373

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