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Activated α(2)-Macroglobulin Binding to Cell Surface GRP78 Induces T-Loop Phosphorylation of Akt1 by PDK1 in Association with Raptor
PDK1 phosphorylates multiple substrates including Akt by PIP(3)-dependent mechanisms. In this report we provide evidence that in prostate cancer cells stimulated with activated α(2)-macroglobulin (α(2)M*) PDK1 phosphorylates Akt in the T-loop at Thr(308) by using Raptor in the mTORC1 complex as a sc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916429/ https://www.ncbi.nlm.nih.gov/pubmed/24516643 http://dx.doi.org/10.1371/journal.pone.0088373 |