Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA

BACKGROUND: The human peptidyl-prolyl isomerase Cyclophilin A (CypA) binds HIV-1 capsid (CA) and influences early steps in the HIV-1 replication cycle. The mechanism by which CypA regulates HIV-1 transduction efficiency is unknown. Disruption of CypA binding to CA, either by genetic means or by the...

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Detalles Bibliográficos
Autores principales: De Iaco, Alberto, Luban, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916700/
https://www.ncbi.nlm.nih.gov/pubmed/24479545
http://dx.doi.org/10.1186/1742-4690-11-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916700/
https://www.ncbi.nlm.nih.gov/pubmed/24479545
http://dx.doi.org/10.1186/1742-4690-11-11

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