Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction and degeneration of motor neurons. Multiple disease-causing mutations, including in the genes for SOD1 and TDP-43, have been identified in ALS. Astrocytes expressing mutant SOD1 are strongly implicated in the pat...

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Detalles Bibliográficos
Autores principales: Rojas, Fabiola, Cortes, Nicole, Abarzua, Sebastian, Dyrda, Agnieszka, van Zundert, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916762/
https://www.ncbi.nlm.nih.gov/pubmed/24570655
http://dx.doi.org/10.3389/fncel.2014.00024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916762/
https://www.ncbi.nlm.nih.gov/pubmed/24570655
http://dx.doi.org/10.3389/fncel.2014.00024

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