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Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction and degeneration of motor neurons. Multiple disease-causing mutations, including in the genes for SOD1 and TDP-43, have been identified in ALS. Astrocytes expressing mutant SOD1 are strongly implicated in the pat...

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Detalles Bibliográficos
Autores principales:	Rojas, Fabiola, Cortes, Nicole, Abarzua, Sebastian, Dyrda, Agnieszka, van Zundert, Brigitte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916762/ https://www.ncbi.nlm.nih.gov/pubmed/24570655 http://dx.doi.org/10.3389/fncel.2014.00024

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