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Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

The force generated by the actomyosin cytoskeleton controls focal adhesion dynamics during cell migration. This process is thought to involve the mechanical unfolding of talin to expose cryptic vinculin-binding sites. However, the ability of the actomyosin cytoskeleton to directly control the format...

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Detalles Bibliográficos
Autores principales: Ciobanasu, Corina, Faivre, Bruno, Le Clainche, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916842/
https://www.ncbi.nlm.nih.gov/pubmed/24452080
http://dx.doi.org/10.1038/ncomms4095