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RNAi Factors are Present and Active in Human Cell Nuclei

RNAi is widely appreciated as a powerful regulator of mRNA translation in the cytoplasm of mammalian cells. However, the presence and activity of RNAi factors in the mammalian nucleus has been the subject of considerable debate. Here we show that Argonaute-2 (Ago2) and RNAi factors Dicer, TRBP and T...

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Detalles Bibliográficos
Autores principales: Gagnon, Keith T., Li, Liande, Chu, Yongjun, Janowski, Bethany A., Corey, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916906/
https://www.ncbi.nlm.nih.gov/pubmed/24388755
http://dx.doi.org/10.1016/j.celrep.2013.12.013