Cargando…
Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
OBJECTIVES: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. MATERIALS AND METHODS: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917163/ https://www.ncbi.nlm.nih.gov/pubmed/24554908 http://dx.doi.org/10.4103/0976-500X.124419 |
_version_ | 1782302797850476544 |
---|---|
author | Elsayed, Mossad Gamaleddin Ahmed Elkomy, Ashraf Abdelhakim Ahmed Gaballah, Mahmoud Salem Elbadawy, Mohamed |
author_facet | Elsayed, Mossad Gamaleddin Ahmed Elkomy, Ashraf Abdelhakim Ahmed Gaballah, Mahmoud Salem Elbadawy, Mohamed |
author_sort | Elsayed, Mossad Gamaleddin Ahmed |
collection | PubMed |
description | OBJECTIVES: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. MATERIALS AND METHODS: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration. RESULTS: Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy. |
format | Online Article Text |
id | pubmed-3917163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39171632014-02-19 Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats Elsayed, Mossad Gamaleddin Ahmed Elkomy, Ashraf Abdelhakim Ahmed Gaballah, Mahmoud Salem Elbadawy, Mohamed J Pharmacol Pharmacother Research Paper OBJECTIVES: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. MATERIALS AND METHODS: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration. RESULTS: Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3917163/ /pubmed/24554908 http://dx.doi.org/10.4103/0976-500X.124419 Text en Copyright: © Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Elsayed, Mossad Gamaleddin Ahmed Elkomy, Ashraf Abdelhakim Ahmed Gaballah, Mahmoud Salem Elbadawy, Mohamed Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats |
title | Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats |
title_full | Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats |
title_fullStr | Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats |
title_full_unstemmed | Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats |
title_short | Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats |
title_sort | nephrotoxicity of cefepime: a new cephalosporin antibiotic in rats |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917163/ https://www.ncbi.nlm.nih.gov/pubmed/24554908 http://dx.doi.org/10.4103/0976-500X.124419 |
work_keys_str_mv | AT elsayedmossadgamaleddinahmed nephrotoxicityofcefepimeanewcephalosporinantibioticinrats AT elkomyashrafabdelhakimahmed nephrotoxicityofcefepimeanewcephalosporinantibioticinrats AT gaballahmahmoudsalem nephrotoxicityofcefepimeanewcephalosporinantibioticinrats AT elbadawymohamed nephrotoxicityofcefepimeanewcephalosporinantibioticinrats |