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Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats

OBJECTIVES: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. MATERIALS AND METHODS: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative...

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Autores principales: Elsayed, Mossad Gamaleddin Ahmed, Elkomy, Ashraf Abdelhakim Ahmed, Gaballah, Mahmoud Salem, Elbadawy, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917163/
https://www.ncbi.nlm.nih.gov/pubmed/24554908
http://dx.doi.org/10.4103/0976-500X.124419
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author Elsayed, Mossad Gamaleddin Ahmed
Elkomy, Ashraf Abdelhakim Ahmed
Gaballah, Mahmoud Salem
Elbadawy, Mohamed
author_facet Elsayed, Mossad Gamaleddin Ahmed
Elkomy, Ashraf Abdelhakim Ahmed
Gaballah, Mahmoud Salem
Elbadawy, Mohamed
author_sort Elsayed, Mossad Gamaleddin Ahmed
collection PubMed
description OBJECTIVES: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. MATERIALS AND METHODS: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration. RESULTS: Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy.
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spelling pubmed-39171632014-02-19 Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats Elsayed, Mossad Gamaleddin Ahmed Elkomy, Ashraf Abdelhakim Ahmed Gaballah, Mahmoud Salem Elbadawy, Mohamed J Pharmacol Pharmacother Research Paper OBJECTIVES: To investigate the nephrotoxic effect and biochemical alterations induced by cefepime in rats. MATERIALS AND METHODS: Cefepime was administered intramuscularly at doses of 45, 90 and 180 mg/kg b.wt. once daily for 5 consecutive days. The serum and urine samples were used for quantitative determination of urea, creatinine, glucose, total protein, calcium, sodium and potassium. The histopathological examination of kidney tissues was performed 1, 4 and 8 days after the last dose of cefepime administration. RESULTS: Cefepime induced a significant increase in the total amount of urine per day, urea and creatinine concentration in the serum and urine and significant decrease in their clearance. Cefepime also caused a significant gluocosuria and proteinuria and significant decrease in their serum concentrations. The effect of cefepime on serum and urine concentrations of calcium, sodium and potassium were also determined. Cefepime injection in the three tested doses caused renal tubular, glomerular and vascular changes. The severity of these changes was dose dependent. In conclusion, these results suggest a possible contribution of cefepime in the nephrotoxicity and biochemical alterations, especially at high doses. Therefore, the renal functions should be monitored during the cefepime therapy. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3917163/ /pubmed/24554908 http://dx.doi.org/10.4103/0976-500X.124419 Text en Copyright: © Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Elsayed, Mossad Gamaleddin Ahmed
Elkomy, Ashraf Abdelhakim Ahmed
Gaballah, Mahmoud Salem
Elbadawy, Mohamed
Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
title Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
title_full Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
title_fullStr Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
title_full_unstemmed Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
title_short Nephrotoxicity of cefepime: A new cephalosporin antibiotic in rats
title_sort nephrotoxicity of cefepime: a new cephalosporin antibiotic in rats
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917163/
https://www.ncbi.nlm.nih.gov/pubmed/24554908
http://dx.doi.org/10.4103/0976-500X.124419
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