TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS

Molecular mechanisms underlying neurodegenerative diseases converge at the interface of pathways impacting cellular stress, protein homeostasis and aging. Targeting the intrinsic capacities of neuroprotective proteins to restore neuronal function and/or attenuate degeneration represents a potential...

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Detalles Bibliográficos
Autores principales: Thompson, Michelle L., Chen, Pan, Yan, Xiaohui, Kim, Hanna, Borom, Akeem R., Roberts, Nathan B., Caldwell, Kim A., Caldwell, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917244/
https://www.ncbi.nlm.nih.gov/pubmed/24311730
http://dx.doi.org/10.1242/dmm.013615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917244/
https://www.ncbi.nlm.nih.gov/pubmed/24311730
http://dx.doi.org/10.1242/dmm.013615

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