The Marine Fungal Metabolite, AD0157, Inhibits Angiogenesis by Targeting the Akt Signaling Pathway

In the course of a screening program for the inhibitors of angiogenesis from marine sources, AD0157, a pyrrolidinedione fungal metabolite, was selected for its angiosupressive properties. AD0157 inhibited the growth of endothelial and tumor cells in culture in the micromolar range. Our results show...

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Detalles Bibliográficos
Autores principales: García-Caballero, Melissa, Cañedo, Librada, Fernández-Medarde, Antonio, Medina, Miguel Ángel, Quesada, Ana R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917274/
https://www.ncbi.nlm.nih.gov/pubmed/24441613
http://dx.doi.org/10.3390/md12010279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917274/
https://www.ncbi.nlm.nih.gov/pubmed/24441613
http://dx.doi.org/10.3390/md12010279

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