Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

Bone formation is exquisitely controlled in space and time. Heterotopic ossification (HO), the pathologic formation of extra-skeletal bone, occurs as a common complication of trauma or in genetic disorders and can be disabling and lethal. However, the underlying molecular mechanisms are largely unkn...

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Detalles Bibliográficos
Autores principales: Regard, Jean B., Malhotra, Deepti, Gvozdenovic-Jeremic, Jelena, Josey, Michelle, Chen, Min, Weinstein, Lee S., Lu, Jianming, Shore, Eileen M., Kaplan, Frederick S., Yang, Yingzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917515/
https://www.ncbi.nlm.nih.gov/pubmed/24076664
http://dx.doi.org/10.1038/nm.3314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917515/
https://www.ncbi.nlm.nih.gov/pubmed/24076664
http://dx.doi.org/10.1038/nm.3314

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