Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis

Tissue-specific knockout (KO) of atypical protein kinase C-λ (PKC-λ) impairs insulin-stimulated glucose transport in muscle (M) and lipid synthesis in liver (L), thereby producing insulin resistance in MλKO mice and insulin-hypersensitivity in LλKO mice. Here, we generated mice with KO of PKC-λ in a...

Descripción completa

Detalles Bibliográficos
Autores principales: Sajan, Mini P, Jurzak, Michael J, Samuels, Varman T, Shulman, Gerald I, Braun, Ursula, Leitges, Michael, Farese, Robert V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917928/
https://www.ncbi.nlm.nih.gov/pubmed/24575365
http://dx.doi.org/10.4161/adip.26305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917928/
https://www.ncbi.nlm.nih.gov/pubmed/24575365
http://dx.doi.org/10.4161/adip.26305

Ejemplares similares