NFκB mediates IL-1β-induced down-regulation of TβRII through the modulation of Sp3 expression

We previously showed that interleukin-1β (IL-1β) down-regulation of type II TGFβ receptor (TβRII) involves NFκB pathway and requires de novo synthesis of a yet unknown protein. Here, we demonstrate that this effect is mediated through Sp1 site located at position -25 of human TβRII promoter. Inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Baugé, C, Beauchef, G, Leclercq, S, Kim, S J, Pujol, J P, Galéra, P, Boumédiene, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918091/
https://www.ncbi.nlm.nih.gov/pubmed/18053089
http://dx.doi.org/10.1111/j.1582-4934.2007.00173.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918091/
https://www.ncbi.nlm.nih.gov/pubmed/18053089
http://dx.doi.org/10.1111/j.1582-4934.2007.00173.x

Ejemplares similares