A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications

RNA interference (RNAi) is an important avenue for target-specific gene silencing that is mainly performed by either small interfering RNAs (siRNAs) or microRNAs (miRNAs). This novel method is rapidly becoming a powerful tool for gene therapy. However, the rapid degradation of siRNAs and miRNAs and...

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Detalles Bibliográficos
Autores principales: Hagiwara, Keitaro, Ochiya, Takahiro, Kosaka, Nobuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918124/
https://www.ncbi.nlm.nih.gov/pubmed/24533256
http://dx.doi.org/10.1007/s13346-013-0180-9
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author Hagiwara, Keitaro
Ochiya, Takahiro
Kosaka, Nobuyoshi
author_facet Hagiwara, Keitaro
Ochiya, Takahiro
Kosaka, Nobuyoshi
author_sort Hagiwara, Keitaro
collection PubMed
description RNA interference (RNAi) is an important avenue for target-specific gene silencing that is mainly performed by either small interfering RNAs (siRNAs) or microRNAs (miRNAs). This novel method is rapidly becoming a powerful tool for gene therapy. However, the rapid degradation of siRNAs and miRNAs and the limited duration of their action in vivo call for an efficient delivery technology. Recently, increasing attention has been paid to the use of extracellular vesicles (EVs) as delivery systems. The use of EVs as small RNA carriers has multiple advantages over conventional delivery systems. In this review, we summarize recent findings regarding the potential application of EVs as small RNA delivery systems. Moreover, we focus on some of the obstacles to EV-based therapeutics.
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spelling pubmed-39181242014-02-14 A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications Hagiwara, Keitaro Ochiya, Takahiro Kosaka, Nobuyoshi Drug Deliv Transl Res Review Article RNA interference (RNAi) is an important avenue for target-specific gene silencing that is mainly performed by either small interfering RNAs (siRNAs) or microRNAs (miRNAs). This novel method is rapidly becoming a powerful tool for gene therapy. However, the rapid degradation of siRNAs and miRNAs and the limited duration of their action in vivo call for an efficient delivery technology. Recently, increasing attention has been paid to the use of extracellular vesicles (EVs) as delivery systems. The use of EVs as small RNA carriers has multiple advantages over conventional delivery systems. In this review, we summarize recent findings regarding the potential application of EVs as small RNA delivery systems. Moreover, we focus on some of the obstacles to EV-based therapeutics. Springer US 2013-10-12 2014 /pmc/articles/PMC3918124/ /pubmed/24533256 http://dx.doi.org/10.1007/s13346-013-0180-9 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review Article
Hagiwara, Keitaro
Ochiya, Takahiro
Kosaka, Nobuyoshi
A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications
title A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications
title_full A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications
title_fullStr A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications
title_full_unstemmed A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications
title_short A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications
title_sort paradigm shift for extracellular vesicles as small rna carriers: from cellular waste elimination to therapeutic applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918124/
https://www.ncbi.nlm.nih.gov/pubmed/24533256
http://dx.doi.org/10.1007/s13346-013-0180-9
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