TNF-α blockade induces IL-10 expression in human CD4+ T cells

IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF-inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-mediated induction of IL-10 in IL-17+ CD4+ T cells is...

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Detalles Bibliográficos
Autores principales: Evans, Hayley G., Roostalu, Urmas, Walter, Gina J., Gullick, Nicola J., Frederiksen, Klaus S., Roberts, Ceri A., Sumner, Jonathan, Baeten, Dominique L., Gerwien, Jens G., Cope, Andrew P., Geissmann, Frederic, Kirkham, Bruce W., Taams, Leonie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918582/
https://www.ncbi.nlm.nih.gov/pubmed/24492460
http://dx.doi.org/10.1038/ncomms4199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918582/
https://www.ncbi.nlm.nih.gov/pubmed/24492460
http://dx.doi.org/10.1038/ncomms4199

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