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Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation

The evolutionarily conserved soluble adenylyl cyclase (sAC, adcy10) was recently identified as a unique source of cAMP in the cytoplasm and the nucleus. Its activity is regulated by bicarbonate and fine-tuned by calcium. As such, and in conjunction with carbonic anhydrase (CA), sAC constitutes an HC...

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Detalles Bibliográficos
Autores principales: Chang, Jung-Chin, Oude-Elferink, Ronald P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918592/
https://www.ncbi.nlm.nih.gov/pubmed/24575049
http://dx.doi.org/10.3389/fphys.2014.00042