Assessment of Mycobacterium bovis Deleted in p27-p55 Virulence Operon as Candidate Vaccine against Tuberculosis in Animal Models

A Mycobacterium bovis knockout in p27-p55 operon was tested as an antituberculosis experimental vaccine in animal models. The mutant MbΔp27-p55 was significantly more attenuated in nude mice than its parental strain but more virulent than BCG Pasteur. Challenge experiments in mice and guinea pigs us...

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Detalles Bibliográficos
Autores principales: Bianco, María V., Clark, Simon, Blanco, Federico C., Garbaccio, Sergio, García, Elizabeth, Cataldi, Angel A., Williams, Ann, Bigi, Fabiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918748/
https://www.ncbi.nlm.nih.gov/pubmed/24588000
http://dx.doi.org/10.1155/2014/951978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918748/
https://www.ncbi.nlm.nih.gov/pubmed/24588000
http://dx.doi.org/10.1155/2014/951978

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