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Control of Glutamine Metabolism By the Tumor Suppressor Rb

Retinoblastoma (Rb) protein is a tumor suppressor that is dysregulated in a majority of human cancers. Rb functions to inhibit cell cycle progression in part by directly disabling the E2F family of cell cycle-promoting transcription factors. Because the de novo synthesis of multiple glutamine-derive...

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Detalles Bibliográficos
Autores principales: Reynolds, Miriam R., Lane, Andrew N., Robertson, Brian, Kemp, Sharen, Liu, Yongqing, Hill, Bradford G., Dean, Douglas C., Clem, Brian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918885/
https://www.ncbi.nlm.nih.gov/pubmed/23353822
http://dx.doi.org/10.1038/onc.2012.635