Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

Ras superfamily GTPase activation and inactivation occur by canonical nucleotide exchange and GTP hydrolysis mechanisms. Despite conservation of active-site residues, the Ras-related Rab GTPase activation pathway differs from Ras and between different Rabs. Analysis of DENND1-Rab35, Rabex-Rab5, TRAP...

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Detalles Bibliográficos
Autores principales: Langemeyer, Lars, Nunes Bastos, Ricardo, Cai, Yiying, Itzen, Aymelt, Reinisch, Karin M, Barr, Francis A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919270/
https://www.ncbi.nlm.nih.gov/pubmed/24520163
http://dx.doi.org/10.7554/eLife.01623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919270/
https://www.ncbi.nlm.nih.gov/pubmed/24520163
http://dx.doi.org/10.7554/eLife.01623

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