Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism

DNA methylation has been proven to be a critical epigenetic mark important for various cellular processes. Here, we report that redox-active quinones, a ubiquitous class of chemicals found in natural products, cancer therapeutics and environment, stimulate the conversion of 5mC to 5hmC in vivo, and...

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Detalles Bibliográficos
Autores principales: Zhao, Bailin, Yang, Ying, Wang, Xiaoli, Chong, Zechen, Yin, Ruichuan, Song, Shu-Hui, Zhao, Chao, Li, Cuiping, Huang, Hua, Sun, Bao-Fa, Wu, Danni, Jin, Kang-Xuan, Song, Maoyong, Zhu, Ben-Zhan, Jiang, Guibin, Rendtlew Danielsen, Jannie M., Xu, Guo-Liang, Yang, Yun-Gui, Wang, Hailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919571/
https://www.ncbi.nlm.nih.gov/pubmed/24214992
http://dx.doi.org/10.1093/nar/gkt1090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919571/
https://www.ncbi.nlm.nih.gov/pubmed/24214992
http://dx.doi.org/10.1093/nar/gkt1090

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