Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila

Although Dicer is essential for general microRNA (miRNA) biogenesis, vertebrate mir-451 is Dicer independent. Instead, its short pre-miRNA hairpin is ‘sliced’ by Ago2, then 3′-resected into mature miRNAs. Here, we show that Drosophila cells and animals generate functional small RNAs from mir-451-typ...

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Detalles Bibliográficos
Autores principales: Yang, Jr-Shiuan, Smibert, Peter, Westholm, Jakub O., Jee, David, Maurin, Thomas, Lai, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919586/
https://www.ncbi.nlm.nih.gov/pubmed/24220090
http://dx.doi.org/10.1093/nar/gkt1038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919586/
https://www.ncbi.nlm.nih.gov/pubmed/24220090
http://dx.doi.org/10.1093/nar/gkt1038

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