Cellular senescence mediated by p16(INK4A)-coupled miRNA pathways

p16 is a key regulator of cellular senescence, yet the drivers of this stable state of proliferative arrest are not well understood. Here, we identify 22 senescence-associated microRNAs (SA-miRNAs) in normal human mammary epithelial cells. We show that SA-miRNAs-26b, 181a, 210 and 424 function in co...

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Detalles Bibliográficos
Autores principales: Overhoff, Marita G., Garbe, James C., Koh, James, Stampfer, Martha R., Beach, David H., Bishop, Cleo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919591/
https://www.ncbi.nlm.nih.gov/pubmed/24217920
http://dx.doi.org/10.1093/nar/gkt1096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919591/
https://www.ncbi.nlm.nih.gov/pubmed/24217920
http://dx.doi.org/10.1093/nar/gkt1096

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