The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs

RluB catalyses the modification of U2605 to pseudouridine (Ψ) in a stem-loop at the peptidyl transferase center of Escherichia coli 23S rRNA. The homolog RluF is specific to the adjacent nucleotide in the stem, U2604. The 1.3 Å resolution crystal structure of the complex between the catalytic domain...

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Detalles Bibliográficos
Autores principales: Czudnochowski, Nadine, Ashley, Gary W., Santi, Daniel V., Alian, Akram, Finer-Moore, Janet, Stroud, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919597/
https://www.ncbi.nlm.nih.gov/pubmed/24214967
http://dx.doi.org/10.1093/nar/gkt1050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919597/
https://www.ncbi.nlm.nih.gov/pubmed/24214967
http://dx.doi.org/10.1093/nar/gkt1050

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