Deep sequencing of large library selections allows computational discovery of diverse sets of zinc fingers that bind common targets

The Cys(2)His(2) zinc finger (ZF) is the most frequently found sequence-specific DNA-binding domain in eukaryotic proteins. The ZF’s modular protein–DNA interface has also served as a platform for genome engineering applications. Despite decades of intense study, a predictive understanding of the DN...

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Detalles Bibliográficos
Autores principales: Persikov, Anton V., Rowland, Elizabeth F., Oakes, Benjamin L., Singh, Mona, Noyes, Marcus B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919609/
https://www.ncbi.nlm.nih.gov/pubmed/24214968
http://dx.doi.org/10.1093/nar/gkt1034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919609/
https://www.ncbi.nlm.nih.gov/pubmed/24214968
http://dx.doi.org/10.1093/nar/gkt1034

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