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Deep sequencing of large library selections allows computational discovery of diverse sets of zinc fingers that bind common targets
The Cys(2)His(2) zinc finger (ZF) is the most frequently found sequence-specific DNA-binding domain in eukaryotic proteins. The ZF’s modular protein–DNA interface has also served as a platform for genome engineering applications. Despite decades of intense study, a predictive understanding of the DN...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919609/ https://www.ncbi.nlm.nih.gov/pubmed/24214968 http://dx.doi.org/10.1093/nar/gkt1034 |