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Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage
By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fractions of DNA catenanes, knots and supercoils to below equilibrium values. How DNA segments are selected to simplify the equilibrium DNA topology is enigmatic, and the b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919613/ https://www.ncbi.nlm.nih.gov/pubmed/24185700 http://dx.doi.org/10.1093/nar/gkt1037 |