Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1

One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway. A central component of the NMD pathway is Upf1, an RNA-dependent ATPase and helic...

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Detalles Bibliográficos
Autores principales: Lasalde, Clarivel, Rivera, Andrea V., León, Alfredo J., González-Feliciano, José A., Estrella, Luis A., Rodríguez-Cruz, Eva N., Correa, María E., Cajigas, Iván J., Bracho, Dina P., Vega, Irving E., Wilkinson, Miles F., González, Carlos I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919615/
https://www.ncbi.nlm.nih.gov/pubmed/24198248
http://dx.doi.org/10.1093/nar/gkt1049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919615/
https://www.ncbi.nlm.nih.gov/pubmed/24198248
http://dx.doi.org/10.1093/nar/gkt1049

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